abstract：:Using optimal control theory as the basic theoretical tool, we investigate the efficacy of different antibiotic treatment protocols in the most exacting of circumstances, described as follows. Viewing a continuous culture device as a proxy for a much more complex host organism, we first inoculate the device with a sin...

journal_title：Bulletin of mathematical biology

authors： Peña-Miller R,Lähnemann D,Schulenburg H,Ackermann M,Beardmore R

更新日期：2012-04-01 00:00:00

abstract：:We derive point and interval estimates for an urban population of green tree frogs (Hyla cinerea) from capture-mark-recapture field data obtained during the years 2006-2009. We present an infinite-dimensional least-squares approach which compares a mathematical population model to the statistical population estimates ...

journal_title：Bulletin of mathematical biology

authors： Ackleh AS,Carter J,Deng K,Huang Q,Pal N,Yang X

更新日期：2012-03-01 00:00:00

abstract：:Gene transcription is a central cellular process and is stochastic in nature. The stochasticity has been studied in real cells and in theory, but often for the transcription activated by a single signaling pathway at steady-state. As transcription of many genes is involved with multiple pathways, we investigate how th...

journal_title：Bulletin of mathematical biology

authors： Sun Q,Tang M,Yu J

更新日期：2012-02-01 00:00:00

abstract：:Based on the logistic growth law for a tumour derived from enzymatic dynamics, we address from a physical point of view the phenomena of synergism, additivity and antagonism in an avascular anti-tumour system regulated externally by dual coupling periodic interventions, and propose a theoretical model to simulate the ...

journal_title：Bulletin of mathematical biology

authors： Hu WY,Zhong WR,Wang FH,Li L,Shao YZ

更新日期：2012-02-01 00:00:00

abstract：:Posttranslational modification of proteins is key in transmission of signals in cells. Many signaling pathways contain several layers of modification cycles that mediate and change the signal through the pathway. Here, we study a simple signaling cascade consisting of n layers of modification cycles such that the modi...

journal_title：Bulletin of mathematical biology

authors： Feliu E,Knudsen M,Andersen LN,Wiuf C

更新日期：2012-01-01 00:00:00

abstract：:In order to understand the role of space in ecological communities where each species produces a certain type of resource and has varying abilities to exploit the resources produced by its own species and by the other species, we carry out a comparative study of an interacting particle system and its mean-field approx...

journal_title：Bulletin of mathematical biology

authors： Kang Y,Lanchier N

更新日期：2012-01-01 00:00:00

abstract：:The surface protein B7-H1, also called PD-L1 and CD274, is found on carcinomas of the lung, ovary, colon, and melanomas but not on most normal tissues. B7-H1 has been experimentally determined to be an antiapoptotic receptor on cancer cells, where B7-H1-positive cancer cells have been shown to be immune resistant, and...

journal_title：Bulletin of mathematical biology

authors： Galante A,Tamada K,Levy D

更新日期：2012-01-01 00:00:00

abstract：:In this paper, we present a mathematical model predicting the fraction of proliferating cells in G1, S, and G2/M phases of the cell cycle as a function of EGFR and HER2. We show that it is possible to find parameters for the mathematical model so that its predictions agree with the experimental observations that HER2 ...

journal_title：Bulletin of mathematical biology

authors： Eladdadi A,Isaacson D

更新日期：2011-12-01 00:00:00

abstract：:Recent advances in virology, gene therapy, and molecular and cell biology have provided insight into the mechanisms through which viruses can boost the anti-tumor immune response, or can infect and directly kill tumor cells. A recent experimental report (Bridle et al. in Molec. Ther. 18(8):1430-1439, 2010) showed that...

journal_title：Bulletin of mathematical biology

authors： Eftimie R,Dushoff J,Bridle BW,Bramson JL,Earn DJ

更新日期：2011-12-01 00:00:00

abstract：:We develop a numerical method for estimating optimal parameters in a mathematical model of the within-host dynamics of malaria infection. The model consists of a quasilinear system of partial differential equations. Convergence theory for the computed parameters is provided. Following this analysis, we present several...

journal_title：Bulletin of mathematical biology

authors： Thibodeaux JJ,Schlittenhardt TP

更新日期：2011-11-01 00:00:00

abstract：:We have programmed a Monte Carlo simulation of the Q-cycle model of electron transport in cytochrome b(6)f complex, an enzyme in the photosynthetic pathway that converts sunlight into biologically useful forms of chemical energy. Results were compared with published experiments of Kramer and Crofts (Biochim. Biophys. ...

journal_title：Bulletin of mathematical biology

authors： Schumaker MF,Kramer DM

更新日期：2011-09-01 00:00:00

abstract：:Synaptic spines grow as a consequence of the formation of F-actin filaments at the spine head. The dynamics of F-actin in the spine head upon excitation of N-methy-D-aspartate (NMDA) receptors has recently been investigated experimentally, but there is no quantitative account of how these dynamic changes occur upon ac...

journal_title：Bulletin of mathematical biology

authors： Bennett MR,Farnell L,Gibson WG

更新日期：2011-09-01 00:00:00

abstract：:Bursting electrical activity is ubiquitous in excitable cells such as neurons and many endocrine cells. The technique of fast/slow analysis, which takes advantage of time scale differences, is typically used to analyze the dynamics of bursting in mathematical models. Two classes of bursting oscillations that have been...

journal_title：Bulletin of mathematical biology

authors： Teka W,Tsaneva-Atanasova K,Bertram R,Tabak J

更新日期：2011-06-01 00:00:00

abstract：:This work aims to examine the global behavior of a Gause type predator-prey model considering two aspects: (i) the functional response is Holling type III and, (ii) the prey growth is affected by the Allee effect. We prove the origin of the system is an attractor equilibrium point for all parameter values. It has also...

journal_title：Bulletin of mathematical biology

authors： González-Olivares E,Rojas-Palma A

更新日期：2011-06-01 00:00:00

abstract：:In this paper, we present a mathematical model describing the effect of polar lipids, excreted by glands in the eyelid and present on the surface of the tear film, on the evolution of a pre-corneal tear film. We aim to explain the interesting experimentally observed phenomenon that the tear film continues to move upwa...

journal_title：Bulletin of mathematical biology

authors： Aydemir E,Breward CJ,Witelski TP

更新日期：2011-06-01 00:00:00

abstract：:Although imatinib is an effective treatment for chronic myelogenous leukemia (CML), and nearly all patients treated with imatinib attain some form of remission, imatinib does not completely eliminate leukemia. Moreover, if the imatinib treatment is stopped, most patients eventually relapse (Cortes et al. in Clin. Canc...

journal_title：Bulletin of mathematical biology

authors： Paquin D,Kim PS,Lee PP,Levy D

更新日期：2011-05-01 00:00:00

abstract：:We study the global stability of a class of models for in-vivo virus dynamics that take into account the Cytotoxic T Lymphocyte immune response and display antigenic variation. This class includes a number of models that have been extensively used to model HIV dynamics. We show that models in this class are globally a...

journal_title：Bulletin of mathematical biology

authors： Souza MO,Zubelli JP

更新日期：2011-03-01 00:00:00

abstract：:Cell motility is an essential phenomenon in almost all living organisms. It is natural to think that behavioral or shape changes of a cell bear information about the underlying mechanisms that generate these changes. Reading cell motion, namely, understanding the underlying biophysical and mechanochemical processes, i...

journal_title：Bulletin of mathematical biology

authors： Coskun H,Coskun H

更新日期：2011-03-01 00:00:00

abstract：:We incorporate a vector-bias term into a malaria-transmission model to account for the greater attractiveness of infectious humans to mosquitoes in terms of differing probabilities that a mosquito arriving at a human at random picks that human depending on whether he is infectious or susceptible. We prove that transcr...

journal_title：Bulletin of mathematical biology

authors： Chamchod F,Britton NF

更新日期：2011-03-01 00:00:00

abstract：:Bacillus subtilis cells may opt to forgo normal cell division and instead form spores if subjected to certain environmental stimuli, for example nutrient deficiency or extreme temperature. The resulting spores are extremely resilient and can survive for extensive periods of time, importantly under particularly harsh c...

journal_title：Bulletin of mathematical biology

authors： Jabbari S,Heap JT,King JR

更新日期：2011-01-01 00:00:00

abstract：:We exhibit a stochastic discrete time model that produces the Eigen model (Naturwissenschaften 58:465-523, 1971) in the deterministic and continuous time limits. The model is based on the competition among individuals differing in terms of fecundity but with the same viability. We explicitly write down the Markov matr...

journal_title：Bulletin of mathematical biology

authors： Musso F

更新日期：2011-01-01 00:00:00

abstract：:Advances in fluorescent labeling of cells as measured by flow cytometry have allowed for quantitative studies of proliferating populations of cells. The investigations (Luzyanina et al. in J. Math. Biol. 54:57-89, 2007; J. Math. Biol., 2009; Theor. Biol. Med. Model. 4:1-26, 2007) contain a mathematical model with fluo...

journal_title：Bulletin of mathematical biology

authors： Banks HT,Sutton KL,Thompson WC,Bocharov G,Roose D,Schenkel T,Meyerhans A

更新日期：2011-01-01 00:00:00

abstract：:While cholera has been a recognized disease for two centuries, there is no strategy for its effective control. We formulate a mathematical model to include essential components such as a hyperinfectious, short-lived bacterial state, a separate class for mild human infections, and waning disease immunity. A new result ...

journal_title：Bulletin of mathematical biology

authors： Miller Neilan RL,Schaefer E,Gaff H,Fister KR,Lenhart S

更新日期：2010-11-01 00:00:00

abstract：:The accuracy of the Fitch method for reconstructing ancestral states on ultrametric phylogenetic trees is studied. Two recurrence relations for computing the accuracy are given here. Using these relations, we analyze the convergence of the accuracy of the Fitch method for reconstructing the root state on a complete bi...

journal_title：Bulletin of mathematical biology

authors： Zhang L,Shen J,Yang J,Li G

更新日期：2010-10-01 00:00:00

abstract：:This paper investigates the dynamics of biomass in a marine ecosystem. A stochastic process is defined in which organisms undergo jumps in body size as they catch and eat smaller organisms. Using a systematic expansion of the master equation, we derive a deterministic equation for the macroscopic dynamics, which we ca...

journal_title：Bulletin of mathematical biology

authors： Datta S,Delius GW,Law R

更新日期：2010-08-01 00:00:00

abstract：:This paper is concerned with early development of transformed epithelial cells (TECs) in the presence of fibroblasts in the tumor micro-environment. These two types of cells interact by means of cytokines such as transforming growth factor (TGF-beta) and epidermal growth factor (EGF) secreted, respectively, by the TEC...

journal_title：Bulletin of mathematical biology

authors： Kim Y,Friedman A

更新日期：2010-07-01 00:00:00

abstract：:In this paper, we study quorum sensing in Pseudomonas aeruginosa biofilms. Quorum sensing is a process where bacteria monitor their population density through the release of extra-cellular signalling molecules. The presence of these molecules affects gene modulation leading to changes in behaviour such as the release ...

journal_title：Bulletin of mathematical biology

authors： Vaughan BL Jr,Smith BG,Chopp DL

更新日期：2010-07-01 00:00:00

abstract：:Small populations at risk of extinction due to threshold or competitive exclusion have a vested interest in rapid growth. Taking chance of survival into account for diploid populations, Fisher's theorem predicts a sex ratio favoring females under certain circumstances. Theoretical consideration of competitive exclusio...

journal_title：Bulletin of mathematical biology

authors： Johnson SD

更新日期：2010-01-01 00:00:00

abstract：:In previous studies, we used a mathematical model of the thick ascending limb (TAL) to investigate nonlinearities in the tubuloglomerular feedback (TGF) loop. That model does not represent other segments of the nephron, the water, and NaCl transport along which may impact fluid flow rate and NaCl transport along the T...

journal_title：Bulletin of mathematical biology

authors： Layton AT,Edwards A

更新日期：2010-01-01 00:00:00

abstract：:The mutation process is introduced into the colored coalescent theory. The mutation process can be viewed as an independent Poisson process running on the colored genealogical random tree generated by the colored coalescent process, with the edge lengths of the random tree serving as the time scale for the mutation pr...

journal_title：Bulletin of mathematical biology

authors： Tian JP,Lin XS

更新日期：2009-11-01 00:00:00

abstract：:We propose a new geometric buildup algorithm for the solution of the distance geometry problem in protein modeling, which can prevent the accumulation of the rounding errors in the buildup calculations successfully and also tolerate small errors in given distances. In this algorithm, we use all instead of a subset of ...

journal_title：Bulletin of mathematical biology

authors： Sit A,Wu Z,Yuan Y

更新日期：2009-11-01 00:00:00

abstract：:Direct reciprocity is a chief mechanism of mutual cooperation in social dilemma. Agents cooperate if future interactions with the same opponents are highly likely. Direct reciprocity has been explored mostly by evolutionary game theory based on natural selection. Our daily experience tells, however, that real social a...

journal_title：Bulletin of mathematical biology

authors： Masuda N,Ohtsuki H

更新日期：2009-11-01 00:00:00

abstract：:The simulation of biological systems is often plagued by a high level of noise in the data, as well as by models containing a large number of correlated parameters. As a result, the parameters are poorly identified by the data, and the reliability of the model predictions may be questionable. Bayesian sampling methods...

journal_title：Bulletin of mathematical biology

authors： Haario H,Kalachev L,Laine M

更新日期：2009-10-01 00:00:00

abstract：:Evolutionary game dynamics of two strategies in finite population is studied by continuous probabilistic approach. Besides frequency dependent selection, mutation was also included in this study. The equilibrium probability density functions of abundance, expected time to extinction or fixation were derived and their ...

journal_title：Bulletin of mathematical biology

authors： Gao M

更新日期：2009-07-01 00:00:00

abstract：:Body size of organisms spans 24 orders of magnitude, and metabolic rate and life span present comparable differences across species. This article shows that this variation can be explained in terms of evolutionary entropy, a statistical parameter which characterizes the robustness of a population, and describes the un...

journal_title：Bulletin of mathematical biology

authors： Demetrius L,Legendre S,Harremöes P

更新日期：2009-05-01 00:00:00

abstract：:First generation HIV vaccines may have limited ability to prevent infection. Instead, they may delay the onset of AIDS or reduce the infectiousness of vaccinated individuals who become infected. To assess the population level effects of such a vaccine, we formulate a deterministic model for the spread of HIV in a homo...

journal_title：Bulletin of mathematical biology

authors： Rida W,Sandberg S

更新日期：2009-04-01 00:00:00

abstract：:One of the main challenges in systems biology is the establishment of the metabolome: a catalogue of the metabolites and biochemical reactions present in a specific organism. Current knowledge of biochemical pathways as stored in public databases such as KEGG, is based on carefully curated genomic evidence for the pre...

journal_title：Bulletin of mathematical biology

authors： Félix L,Rosselló F,Valiente G

更新日期：2009-04-01 00:00:00

abstract：:Knowledge about large-scale and long-term dynamics of (natural) populations is required to assess the efficiency of control strategies, the potential for long-term persistence, and the adaptability to global changes such as habitat fragmentation and global warming. For most natural populations, such as pest population...

journal_title：Bulletin of mathematical biology

authors： Soubeyrand S,Neuvonen S,Penttinen A

更新日期：2009-02-01 00:00:00

abstract：:Many neurons in mammalian sensory systems exhibit On and Off responses when given appropriate excitatory and inhibitory stimuli. In some instances, such neurons can also exhibit a Mixed response where diminished On and Off responses are both present. In this manuscript, we present a simple single cell model for these ...

journal_title：Bulletin of mathematical biology

authors： Latulippe J,Pernarowski M

更新日期：2009-01-01 00:00:00

abstract：:We consider a kinetic law of mass action model for Fibroblast Growth Factor (FGF) signaling, focusing on the induction of the RAS-MAP kinase pathway via GRB2 binding. Our biologically simple model suffers a combinatorial explosion in the number of differential equations required to simulate the system. In addition to ...

journal_title：Bulletin of mathematical biology

authors： Gaffney EA,Heath JK,Kwiatkowska MZ

更新日期：2008-11-01 00:00:00